Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 21, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

A Konate, M Diarra, D Minta

    Le Mali Medical
    |July 21, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    The Availability Heuristic01:08

    The Availability Heuristic

    A heuristic is a general problem-solving framework (Tversky & Kahneman, 1974). You can think of these as mental shortcuts that are used to solve problems. Different types of heuristics are used in different types of situations, and the impulse to use a heuristic occurs when one of five conditions is met (Pratkanis, 1989):

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Management of women with abnormal cervical cytology: Update of French guidelines after the implementation of HPV screening.

    European journal of obstetrics, gynecology, and reproductive biology·2025
    Same author

    [Histo-Molecular Profiles Of Male Breast Cancers In Mali].

    Le Mali medical·2024
    Same author

    [Internal Hemorroïd Disease In Digestive Endoscopy Center Of Chu Gabriel Toure Of Bamako].

    Le Mali medical·2024
    Same author

    [Role Of Imaging In The Management Of A Case Of Intrauterine Device Migration].

    Le Mali medical·2024
    Same author

    [Internal Hemorroïd Disease In Digestive Endoscopy Center Of Chu Gabriel Toure Of Bamako].

    Le Mali medical·2024
    Same author

    [Infection with the Hepatitis B virus in pregnant women in the Gynecology and Obstetrics Department of the Gabriel Touré University Hospital Center].

    Le Mali medical·2024
    Same journal

    [Factors associated with Covid 19 vaccines Hesitancy in Mali, household survey, 2021].

    Le Mali medical·2024
    Same journal

    [Prevalence Of Mental Disorders And Addictive Behaviours Among Artisanal Gold Miners In Burkina Faso].

    Le Mali medical·2024
    Same journal

    [Factors associated with mortality in patients with COVID-19 in the Tambacounda region, Senegal, 2020-2021].

    Le Mali medical·2024
    Same journal

    [Factors Associated With Neonatal Mortality In Diamare, Cameroon].

    Le Mali medical·2024
    Same journal

    [Giant Ossifiant Fibrome Of The Mandibule In The Adolescent At The National Center D'odonto-Stomatologie Of Bamako].

    Le Mali medical·2024
    Same journal

    [Post-Vaccination Adverse Events Related To The Administration Of The Covishield® Coronavirus Vaccine In Vaccinated Volunteers At The Bamako Dermatology Hospital From April To June 2021].

    Le Mali medical·2024
    See all related articles

    Hepatitis C virus (HCV) significantly impacts liver disease in Mali. This study found high HCV seroprevalence in cirrhosis and hepatocellular carcinoma patients, with genotype 2a/2c being most common.

    Area of Science:

    • Hepatology
    • Virology
    • Epidemiology

    Background:

    • Chronic liver diseases, including cirrhosis and hepatocellular carcinoma, pose a significant health burden globally.
    • Hepatitis C virus (HCV) is a major etiological factor for chronic liver disease worldwide.
    • Understanding HCV seroprevalence and genotype distribution is crucial for disease management and prevention strategies, particularly in resource-limited settings.

    Purpose of the Study:

    • To determine the seroprevalence and genotypes of Hepatitis C Virus (HCV) in patients with chronic liver diseases (cirrhosis and hepatocellular carcinoma) in Bamako, Mali.
    • To compare HCV seroprevalence in patients with chronic liver diseases to a control group of blood donors.
    • To assess the role of HCV in the pathogenesis of cirrhosis and hepatocellular carcinoma in the study population.

    Related Experiment Videos

    Last Updated: Jun 21, 2026

    High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
    12:33

    High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

    Published on: November 15, 2013

    Main Methods:

    • A cross-sectional study was conducted in Bamako, Mali.
    • Participants included 91 patients with chronic liver diseases (53 cirrhosis, 38 hepatocellular carcinoma) and 92 healthy blood donors as controls.
    • Enzyme-linked immunosorbent assay (ELISA) was used for initial screening, with positive results confirmed by Recombinant Immunoblot Assay (RIBA). HCV genotyping was performed on positive samples.

    Main Results:

    • Overall HCV seroprevalence was 15.4% in liver disease patients (15.1% in cirrhosis, 21% in hepatocellular carcinoma) compared to 2.2% in blood donors.
    • False positive reactions were observed with ELISA (3.3% in patients, 1.1% in controls) but were excluded after RIBA confirmation.
    • Hepatitis B virus (HBV) surface antigen (HBsAg) was associated in 5.6% of HCV-positive cases.
    • HCV genotype 2a/2c was highly prevalent (85.7%) among the HCV-positive patients.

    Conclusions:

    • HCV plays a significant role in the development of cirrhosis and hepatocellular carcinoma in Mali.
    • The high prevalence of genotype 2a/2c suggests specific transmission dynamics or etiological patterns in the region.
    • Routine screening for HCV in patients with chronic liver disease and blood donors is recommended in Mali.