Ophthalmic presentation of plasma cell neoplasm

Area of Science:

• Ophthalmology
• Oncology
• Pathology

Background:

• Plasma cell neoplasms are rare tumors.
• Lacrimal sac tumors are uncommon, with varied histopathology.
• Extramedullary plasma cell tumors can occur systemically.

Observation:

• A 64-year-old man presented with a plasma cell neoplasm in the right lacrimal sac.
• The initial tumor was treated with surgery and radiation, followed by a local recurrence that also responded to radiation.
• A distant plasma cell neoplasm developed in the humerus.

Findings:

• The patient experienced a localized lacrimal sac plasma cell neoplasm with both local and distant metastases.
• Despite the widespread nature of the plasma cell neoplasms, the patient showed no evidence of multiple myeloma.
• This case highlights the potential for plasma cell neoplasms to present in unusual locations and behave independently of systemic disease.

Implications:

• This case expands the understanding of the clinical spectrum of plasma cell neoplasms.
• It underscores the importance of thorough evaluation for systemic disease in patients with extramedullary plasma cell tumors.
• Further research into the pathogenesis and behavior of these rare neoplasms is warranted.