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Updated: Dec 31, 2025

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Successful thrombolytic therapy for stuck mitral mechanical valve
Hamoud Y Obied1, Mohammed F Ibrahim, Bendehiba S Latroche
1Prince Salman Heart Center, King Fahad Medical City, Riyadh 11525, Kingdom of Saudi Arabia. obeidha@yahoo.com
Mechanical prosthetic valve thrombosis is a rare cardiac complication. This case study shows successful treatment of mitral valve thrombosis using streptokinase infusion therapy.
Area of Science:
- Cardiology
- Cardiac Surgery
- Thrombosis Research
Background:
- Mechanical prosthetic valves are used in cardiac valve replacement surgery.
- Thrombosis, or clot formation, is a rare but serious complication of these valves.
- Early detection and treatment are crucial for patient outcomes.
Observation:
- A case of mechanical prosthetic valve thrombosis in the mitral position is presented.
- The thrombus measured 8 x 14 mm.
- The patient had an On-X mechanical prosthetic valve (31/33 mm).
Findings:
- Intravenous thrombolytic therapy with streptokinase was administered.
- The infusion lasted 10 hours and was repeated twice.
- The treatment was successful with no reported complications.
Implications:
- This case demonstrates the potential efficacy of streptokinase infusion for managing mechanical prosthetic valve thrombosis.
- Successful thrombolysis may offer an alternative to surgical intervention in select cases.
- Further research is warranted to establish optimal thrombolytic protocols for prosthetic valve thrombosis.
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