Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Research overview-2025: integrating scientific progress to accelerate global tuberculosis elimination.

Frontiers in tuberculosis·2026
Same author

Trust, autonomy, and informed consent: a qualitative investigation of youth experiences accessing contraception in Canada.

Sexual and reproductive health matters·2026
Same author

Large Tuberculosis Outbreaks - United States, 2017-2023.

MMWR. Morbidity and mortality weekly report·2026
Same author

Evaluating Tuberculosis Surveillance Using Global Standards and Benchmarks in the Philippines: Mixed Methods Study.

JMIR public health and surveillance·2026
Same author

Using genomic epidemiology and geographic activity spaces to investigate tuberculosis outbreaks in Botswana.

International journal of health geographics·2026
Same author

Tuberculosis Cases and Deaths Averted by PEPFAR.

The New England journal of medicine·2026

Related Experiment Video

Updated: Jun 21, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
07:35

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Published on: April 25, 2014

Two tuberculosis genotyping clusters, one preventable outbreak.

Ann M Buff1, Lynn E Sosa, Andrea J Hoopes

  • 1Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. ali3@cdc.gov

Public Health Reports (Washington, D.C. : 1974)
|July 22, 2009
PubMed
Summary

A tuberculosis (TB) outbreak in 2006 was linked to a single source patient with incomplete treatment and housing instability. Early diagnosis and adequate treatment could have prevented this extensive TB transmission.

More Related Videos

Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples
06:07

Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples

Published on: June 6, 2025

Amplicon Sequencing using the Long-Read Sequencing Technologies
08:57

Amplicon Sequencing using the Long-Read Sequencing Technologies

Published on: August 29, 2025

Related Experiment Videos

Last Updated: Jun 21, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
07:35

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Published on: April 25, 2014

Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples
06:07

Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples

Published on: June 6, 2025

Amplicon Sequencing using the Long-Read Sequencing Technologies
08:57

Amplicon Sequencing using the Long-Read Sequencing Technologies

Published on: August 29, 2025

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Microbiology

Background:

  • Tuberculosis (TB) remains a significant global health concern.
  • Outbreaks highlight the importance of treatment adherence and timely diagnosis.
  • Molecular genotyping plays a crucial role in tracking TB transmission.

Purpose of the Study:

  • To investigate a 2006 tuberculosis outbreak.
  • To identify the source patient and transmission dynamics.
  • To evaluate factors contributing to extensive TB spread.

Main Methods:

  • Genotyping of Mycobacterium tuberculosis isolates using spoligotyping and MIRU-VNTR.
  • Traditional epidemiologic investigation including case interviews and contact tracing.
  • Analysis of patient history, including treatment adherence and housing status.

Main Results:

  • Nine TB cases, including eight community and one incarceration-related, were identified.
  • Molecular methods linked secondary cases to a single source patient.
  • The source patient had a history of incomplete TB treatment, incarceration, and housing instability, contributing to transmission.
  • Mixed Mycobacterium tuberculosis populations were observed in the source patient's isolates.

Conclusions:

  • Incomplete initial TB treatment and delayed diagnosis in the source patient led to extensive transmission.
  • Factors such as incarceration and housing instability facilitated the outbreak.
  • Early diagnosis and adequate treatment of TB are critical for preventing community-wide outbreaks.