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Efficacy of intravenous infusion of doripenem

Marcos I Restrepo1

  • 1University of Texas Health Science Center San Antonio and Audie L. Murphy Division, VERDICT/South Texas Veterans Health Care System, 7400 Merton Minter Blvd., San Antonio, TX 78229, USA. restrepom@uthscsa.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|July 22, 2009
PubMed

Insights

Doripenem demonstrated noninferiority to standard treatments for nosocomial pneumonia (NP) and ventilator-associated pneumonia (VAP). This broad-spectrum carbapenem is effective against multidrug-resistant pathogens, including Pseudomonas aeruginosa.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Pharmacology

Background:

  • Empirical antibiotic treatment is standard for nosocomial pneumonia (NP), including ventilator-associated pneumonia (VAP).
  • Broad-spectrum antibiotics active against multidrug-resistant pathogens are crucial for favorable outcomes in NP-VAP.
  • Doripenem is a novel carbapenem with broad-spectrum and antipseudomonal activity.

Purpose of the Study:

  • To evaluate the efficacy and safety of doripenem compared to standard regimens for NP-VAP.
  • To assess doripenem's performance in high-risk patient subgroups, including those with multidrug-resistant infections.

Main Methods:

  • Post hoc analysis of pooled data from two prospective, randomized, open-label, phase 3 trials.
  • Comparison of doripenem versus imipenem and piperacillin-tazobactam for NP-VAP.
  • Subgroup analyses focused on late-onset VAP, Pseudomonas aeruginosa infections, and bacteremia.

Main Results:

  • Doripenem showed noninferiority to comparator regimens in terms of clinical and microbiological outcomes.
  • Noninferiority was maintained in high-risk subgroups, including patients with late-onset VAP and those with Pseudomonas aeruginosa or bacteremia.
  • Doripenem demonstrated efficacy against multidrug-resistant pathogens.

Conclusions:

  • Doripenem is a viable and effective treatment option for nosocomial pneumonia, including ventilator-associated pneumonia.
  • Its efficacy in high-risk populations supports its role in managing complex NP-VAP cases.
  • Doripenem offers a valuable alternative for empirical treatment of NP-VAP, particularly when multidrug-resistant organisms are suspected.

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