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Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Receptor-Mediated Endocytosis01:20

Receptor-Mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...

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Related Experiment Video

Updated: Jun 21, 2026

Detection of Mitophagy in Caenorhabditis elegans and Mammalian Cells Using Organelle-Specific Dyes
11:59

Detection of Mitophagy in Caenorhabditis elegans and Mammalian Cells Using Organelle-Specific Dyes

Published on: May 19, 2023

A receptor for eating mitochondria.

Naotada Ishihara1, Noboru Mizushima

  • 1Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan. ishihara.phy2@tmd.ac.jp

Developmental Cell
|July 22, 2009
PubMed
Summary

Researchers identified a new mitochondrial surface receptor that controls how cells degrade mitochondria through autophagy. This discovery sheds light on how host cells regulate mitochondrial life and death.

Area of Science:

  • Cell Biology
  • Mitochondrial Biology
  • Autophagy

Background:

  • Mitochondria are crucial for cellular energy production and apoptosis regulation.
  • Host cells actively control mitochondrial dynamics, including growth, fission, and degradation.
  • Mitochondrial autophagy (mitophagy) is a key process for maintaining cellular health.

Purpose of the Study:

  • To identify key regulators of mitochondrial autophagy.
  • To understand the host cell's control over mitochondrial life and death.

Main Methods:

  • Yeast genetics was employed to screen for genes involved in mitochondrial autophagy.
  • Functional analysis of identified genes and proteins.

Main Results:

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Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria

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Detection of Mitophagy in Caenorhabditis elegans and Mammalian Cells Using Organelle-Specific Dyes
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Imaging of mtHyPer7, a Ratiometric Biosensor for Mitochondrial Peroxide, in Living Yeast Cells
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Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria
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Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria

Published on: January 7, 2022

  • A novel mitochondrial surface receptor was identified.
  • This receptor plays a role in the autophagic degradation of mitochondria.

    • Conclusions:

    • The identified receptor is a critical component of the host cell machinery controlling mitophagy.
    • This finding advances our understanding of mitochondrial quality control mechanisms.