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[Comparative studies of hemorheological parameters in Tibet mini-pigs, Beagle dogs and human]
Jin Yuan1, Qing-Hong Wu, Li Chen
1Laboratory Animal Center, Southern Medical University, Guangzhou 510515, China. yjin01@126.com
Objective:
To investigate the relationship of hemorheological parameters between Tibet mini-pigs, Beagle dogs and human.
Methods:
Blood samples were collected from adult Tibet mini-pigs, Beagle dogs and human to detect such hemorheological parameters as the whole blood viscosity (WBV) (high, middle, and low shear rate), PV, HCT, ESR and Fi.
Results:
The male Tibet mini-pigs had significantly lower WBV (150, 30, 5, and 1 s(-1)) and Fi than the female mini-pigs (P<0.05, 0.01, 0.05, 0.01, and 0.01, respectively). The WBV of male Beagle dogs (150 and 1 s(-1)) was significantly lower that in than female dogs (P<0.05). The WBV of male human subjects (1 s(-1)) and HCT were significantly higher, but ESR significantly lower than those in female human subjects P<0.05, 0.01 and 0.01, respectively). WBV (1 s(-1)), PV, and ESR in Beagle dogs were significantly lower, but HCT and Fi significantly higher than those in Tibet mini-pig and human subjects (P<0.05, 0.01, 0.05, and 0.01, respectively). All the hemorheological parameters were similar between Tibet mini-pigs and human (P<0.05).
Conclusion:
The hemorheological parameters of Tibet mini-pigs are closer to those of human than those of Beagle dogs.
