Related Experiment Videos

Cyclosporine-induced infantile nodulocystic acne

Jamison E Strahan1, Joanna M Burch

  • 1Department of Dermatology, The Children's Hospital, Aurora, CO 80045, USA. Jamison.Strahan@ucdenver.edu

Archives of Dermatology
|July 22, 2009
PubMed

Insights

Cyclosporine can cause nodulocystic acne in children, similar to adults. This condition can be effectively treated by stopping cyclosporine and using isotretinoin, with a multidisciplinary approach recommended for transplant patients.

Area of Science:

  • Pediatric Dermatology
  • Transplant Medicine
  • Pharmacology

Background:

  • Cyclosporine is known to induce nodulocystic acne in adult organ transplant recipients.
  • The acnegenic effects of cyclosporine and treatment responses in pediatric populations remain less understood.

Observation:

  • A 9-month-old infant developed facial nodulocystic acne following initiation of cyclosporine therapy post-heart transplantation.
  • The infant's condition improved with the cessation of cyclosporine and the administration of isotretinoin.

Findings:

  • Cyclosporine can induce nodulocystic acne in pediatric patients, mirroring effects seen in adults.
  • Cessation of cyclosporine therapy combined with isotretinoin treatment is an effective management strategy for pediatric cyclosporine-induced acne.

Implications:

  • The findings suggest a parallel between adult and pediatric responses to cyclosporine-induced acne.
  • Management of cyclosporine-induced acne in pediatric transplant recipients requires careful consideration due to potential impacts on overall transplant outcomes.
  • A multidisciplinary approach is crucial for managing pediatric transplant patients experiencing adverse drug reactions like acne.
Abstract

Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...