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Published on: December 23, 2022
Carcinoma of the uterine cervix with squamous and sebaceous differentiation
Clara Rizzardi1, Tiziana Perin, Manuela Schneider
1Department of Pathology of the University of Trieste, Trieste, Italy. crizzardi@units.it
Abstract:
Sebaceous neoplasms, including carcinoma, can exceptionally arise in extracutaneous sites. We present the third known case of carcinoma with sebaceous differentiation in the uterine cervix. Histologic and immunohistochemical features suggested a metaplastic process within an otherwise usual squamous cell carcinoma. We speculate that, by analogy with the skin where the epidermis and the 3 types of adnexa have a common embryologic origin from basal cell layer of the superficial ectoderm, it is possible that endocervical reserve cells, in addition to the well-known capacity of squamous differentiation, retain the potential to give rise to appendages including sebaceous glands.
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