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Updated: Jun 21, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
Depressive disorders in stroke patients
1Department of Neurology and Neurosurgery, Russian State Medical University, Moscow, Russia.
Abstract:
Post-stroke depression is a serious complication of ischemic stroke which has negative influences on patients' quality of life and on recovery from symptoms and the prognosis of the underlying disease. We report here a study of the efficacy of treatment of patients with post-stroke depression with Opra, showing improvements in status in 93.3% of patients. Along with its antidepressant action, Opra had a marked anxiolytic effect. The agent had no adverse effects on the activities of daily living or cognitive functions, and produced minimal side effects.
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