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Updated: Jun 21, 2026
07:59
Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
[Microsatellite alternation in laryngeal squamous cell carcinomas]
Feifei Chen1, Wei Zhu, Bing Liu
1Department of Otorhinolaryngology-Head and Neck Surgery, the First Hospital of Medical College, Jilin University, Changchun, 130021, China.
Summary
Microsatellite instability and loss of heterozygosity are key in laryngeal squamous cell carcinomas. These genetic alterations correlate with tumor stage, particularly at chromosome regions 3p14 and 5q23.
Area of Science:
- Oncology
- Genetics
Context:
- Laryngeal squamous cell carcinoma (LSCC) is a significant global health concern.
- Understanding the genetic underpinnings of LSCC is crucial for developing targeted therapies.
Purpose:
- To investigate the role of microsatellite instability (MSI) and loss of heterozygosity (LOH) in the pathogenesis of LSCC.
- To identify specific chromosomal regions associated with these genetic alterations in LSCC.
Summary:
- This study analyzed 40 LSCC cases, comparing tumor and normal tissues using microsatellite markers on chromosomes 3, 5, and 11.
- Results showed MSI or LOH in 87.5% of samples, with high frequencies at D5S592 (70%) and D3s1228 (52.5%).
- Tumor suppressor genes near chromosome 3p14 and 5q23 regions are implicated in LSCC pathogenesis, with MSI/LOH correlations to tumor stage at D3s1228 and D5s592.
Impact:
- Identifies specific genetic markers (MSI/LOH) involved in LSCC development.
- Suggests potential diagnostic or prognostic biomarkers based on chromosomal alterations.
- Provides insights into the molecular mechanisms driving LSCC progression.
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