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Solid lipid nanoparticles bearing oxybenzone: in-vitro and in-vivo evaluation
Arvind Gulbake1, Aviral Jain, Piush Khare
1Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Vishwavidyalaya, Sagar, India.
Journal of Microencapsulation
|July 23, 2009
Summary
Solid Lipid Nanoparticles (SLNs) enhance sunscreen effectiveness by improving skin retention and sun protection. This formulation offers prolonged UV defense compared to traditional sunscreens.
Area of Science:
- Pharmaceutical Sciences
- Nanotechnology
- Dermatology
Background:
- Oxybenzone is a common UV filter in sunscreens.
- Improving sunscreen efficacy and skin retention is crucial for effective UV protection.
Purpose of the Study:
- To develop Solid Lipid Nanoparticles (SLNs) loaded with oxybenzone to enhance its sunscreen properties.
- To evaluate the in vitro and in vivo performance of oxybenzone-loaded SLNs in a cream base.
Main Methods:
- SLNs were prepared using the ethanol injection method.
- Characterization included particle size, polydispersity index, zeta potential, and surface morphology.
- Formulations were assessed for drug release, sun protection factor (SPF), and skin retention using Confocal Laser Scanning Microscopy (CLSM).
Main Results:
- Optimized SLNs exhibited suitable physicochemical properties.
- The cream formulation with SLNs showed slower oxybenzone release and a higher SPF (>25) compared to the plain cream.
- CLSM confirmed prolonged retention of SLNs within the stratum corneum.
Conclusions:
- Solid Lipid Nanoparticles effectively enhance the sun protection capabilities of oxybenzone.
- SLN-based sunscreen formulations demonstrate improved skin retention and prolonged UV protection.
