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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and the...
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Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Related Experiment Video

Updated: Jun 21, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Irinotecan use during pregnancy.

Justin Taylor1, Adanna Amanze, Elaine Di Federico

  • 1From the Division of Hematology Oncology, University of New Mexico Cancer Center, and Department of Gynecology and Obstetrics, University of New Mexico, Albuquerque, New Mexico.

Obstetrics and Gynecology
|July 23, 2009
PubMed
Summary
This summary is machine-generated.

This case study shows that irinotecan chemotherapy, combined with 5-fluorouracil and folinic acid, can be safely administered during pregnancy for ovarian tumors. The treatment resulted in a healthy neonate with no teratogenic effects observed.

Related Experiment Videos

Last Updated: Jun 21, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Area of Science:

  • Oncology
  • Maternal-Fetal Medicine
  • Reproductive Medicine

Background:

  • Ovarian tumors during pregnancy are uncommon.
  • Limited clinical data exists on the safety of chemotherapy for pregnant patients with ovarian cancer.

Observation:

  • A 34-year-old pregnant woman at 15.5 weeks gestation was diagnosed with a Krukenberg tumor via ultrasonography.
  • She underwent surgical tumor removal followed by 10 cycles of adjuvant chemotherapy.

Findings:

  • The chemotherapy regimen included 5-fluorouracil, folinic acid, and irinotecan, administered every two weeks until the 36th week of gestation.
  • The neonate was delivered without complications and exhibited normal development at 4 months of age, showing no teratogenic effects.

Implications:

  • This case suggests irinotecan chemotherapy can be safely used at full adjuvant doses starting in the second trimester of pregnancy.
  • Further research is warranted to establish definitive safety profiles for chemotherapy during pregnancy.