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Published on: October 5, 2012
[Studies of in vitro releasing properties on cyclovirobuxine D matrix-type patch]
Yang Yu1, Liling Zhou, Xiumei Li
1Department of Pharmaceutics, Guangzhou of Traditional Chinese Medicine, Guangzhou 510006, China. yuyang@gzhtcm.edu.cn
Objective:
To study the drug releasing properties of Cyclovirobuxine D matrix-type patch.
Method:
To prepare Cyclovirobuxine D single-layered and double-layered patch was prepared and the study the drug releasing properties by in vitro releasing and in vitro skin permeation experiments was studied.
Result:
The coefficient of first-order dynamical equation was good for single-layered patch, which means the releasing rate decreased with the amounts of drug decreasing. Nevertheless, Higuchi equation was good for double-layered patch, which means it belonged framing-type releasing system. In-vitro skin permeation experiment showed that zero-order dynamical equation was good for these two patches which indicated all of them abided by Ficks diffusion law.
Conclusion:
The structure of patch can change the drug releasing properties, the double-layered patch can obtain steady releasing and permeating rate because of storage layer releasing.
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