Related Experiment Video
Updated: Jun 21, 2026
11:10
Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
Published on: December 27, 2010
A new HLA-B*5124 variant, B*512402 allele, identified by sequence-based typing
Tissue Antigens
|July 24, 2009
Summary
A new human leukocyte antigen-B allele, B*512402, was discovered in a Korean bone marrow donor. This novel allele has two nucleotide changes but no resulting amino acid alterations compared to B*512401.
Area of Science:
- Immunogenetics
- Molecular Biology
- Human Leukocyte Antigen (HLA) research
Background:
- The human leukocyte antigen (HLA) system plays a critical role in immune response and transplantation.
- Accurate HLA typing is essential for successful bone marrow transplantation.
- Novel HLA allele discovery contributes to a deeper understanding of immune diversity.
Purpose of the Study:
- To report the identification and characterization of a novel human leukocyte antigen-B allele.
- To provide detailed information on the genetic variations of the new allele.
Main Methods:
- DNA sequencing of the HLA-B gene from a Korean bone marrow donor.
- Bioinformatic analysis to compare the novel sequence with known HLA alleles.
- Nucleotide and amino acid sequence comparison.
Main Results:
- A novel HLA-B allele, designated B*512402, was identified.
- B*512402 differs from B*512401 by two nucleotide substitutions in exon 3 (codons 135 and 138).
- These nucleotide substitutions do not result in any amino acid changes.
Conclusions:
- The discovery of B*512402 expands the known HLA-B allele repertoire.
- This finding highlights the importance of ongoing HLA typing for identifying genetic diversity.
- Understanding such variations is crucial for optimizing donor-recipient matching in bone marrow transplantation.
