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[Kidney cell damage and liberation of enzymes]
1Abteilung Nephrologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Bundesrepublik Deutschland.
Wiener Klinische Wochenschrift. Supplementum
|January 1, 1991
Abstract:
The pathophysiological and pathobiochemical background of enzymuria in patients with renal involvement in discussed. Selected markers of the human nephron such as angiotensinase-A, aminopeptidase-M, L-gamma-glutamyl-transferase and dipeptidylpeptidase-IV are characterized; inductive as well as ischaemic/toxic events may induce increased shedding of membrane bound marker-enzymes. Pathological enzyme excretion profiles related to defined renal diseases indicate that tissue-proteinuria of renal origin is a potential noninvasive tool for diagnostic purposes.