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Related Experiment Video

Updated: Jun 21, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Hodgkin lymphoma with cutaneous involvement.

Cyrus C Hsia¹, Kang Howson-Jan, Kamilia S Rizkalla

¹Department of Medicine, Division of Hematology, London Health Sciences Centre, London, Ontario, Canada. chsia@uwo.ca

Dermatology Online Journal

|July 24, 2009

Summary

A rare case of Hodgkin lymphoma presenting as a skin ulcer shows that standard therapy can lead to a good prognosis, challenging previous beliefs about poor outcomes for skin involvement.

Area of Science:

Oncology
Dermatology
Hematology

Background:

Hodgkin lymphoma (HL) typically does not involve the skin.
Cutaneous involvement in HL is exceptionally rare, often associated with advanced disease and poor prognosis.
Previous literature suggests a dismal outlook for HL with skin infiltration.

Observation:

A 54-year-old previously healthy male presented with a solitary cutaneous ulcer.
The ulcer was diagnosed as Hodgkin lymphoma.
This presentation is highly unusual for HL compared to non-Hodgkin lymphoma subtypes.

Findings:

Despite the rarity and typically poor prognosis, the patient responded well to standard HL therapy.
The case challenges the established notion that skin infiltration in HL invariably leads to a poor outcome.

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Last Updated: Jun 21, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Successful treatment with conventional methods was achieved.

Implications:

This case suggests that Hodgkin lymphoma with cutaneous manifestations may not always have a poor prognosis.
It highlights the importance of considering HL in the differential diagnosis of unexplained skin ulcers.
Further research may be warranted to explore treatment strategies for HL skin involvement.