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Updated: Jun 21, 2026
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
[Autoimmune thyroid disease: autoimmune gastritis association's possibility]
F Pita Gutiérrez1, D Crespo Marcos, C Iglesias Fernández
1Unidad de Metabolismo y Endocrinología Pediátrica, Hospital Infantil Gregorio Marañón, Madrid, España.
Anales De Pediatria (Barcelona, Spain : 2003)
|July 24, 2009
Summary
Parietal cell antibodies (PCA) are not common in children with autoimmune thyroid disease (AITD). However, PCA can be an early marker for autoimmune gastritis in pediatric patients.
Area of Science:
- Pediatric Endocrinology
- Gastroenterology
- Immunology
Context:
- Autoimmune thyroid disease (AITD) is prevalent in children.
- Parietal cell antibodies (PCA) are often found in children with AITD.
- The link between AITD and autoimmune gastritis in pediatric populations requires further investigation.
Purpose:
- To determine the prevalence of autoimmune gastritis markers in children diagnosed with AITD.
- To assess the utility of PCA as an early indicator of autoimmune gastritis in this cohort.
Summary:
- This study examined 26 children with AITD, analyzing hemogram, vitamin B12, folic acid, gastrin levels, and PCA.
- While most autoimmune markers were normal, 6 patients had type 1 diabetes mellitus and 2 had celiac disease.
- Only one patient, a 14-year-old hyperthyroid girl, tested positive for PCA, indicating a low prevalence in this group but highlighting its potential as a sensitive marker.
Impact:
- Autoimmune thyroid disease in children and adolescents is frequently associated with other autoimmune conditions, notably type 1 diabetes mellitus and celiac disease.
- Parietal cell antibodies (PCA) serve as a sensitive early marker for detecting autoimmune gastritis in pediatric patients.
- This research underscores the importance of screening for associated autoimmune diseases in children diagnosed with AITD.
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