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Analyzing and Building Nucleic Acid Structures with 3DNA
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Analysis of a complete DNA-protein affinity landscape

William Rowe1, Mark Platt, David C Wedge

  • 1Manchester Interdisciplinary Biocentre, University of Manchester , 131 Princess Street, Manchester M1 7DN, UK. william.rowe@manchester.ac.uk

Journal of the Royal Society, Interface
|July 24, 2009
PubMed
Summary

Researchers mapped the complete protein-binding landscape of a 10-base nucleic acid oligomer. This experimental approach revealed a rugged fitness landscape, offering new insights into biomolecular properties.

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