Related Experiment Video
Updated: Jun 21, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Social activity and improvement in depressive symptoms in older people: a prospective community cohort study
Vivian Isaac1, Robert Stewart, Sylvaine Artero
1King's College London, Institute of Psychiatry, Section of Epidemiology, London, UK.
Objective:
To investigate: i) the association between level of social activity and late-life depressive symptoms and ii) the association between level of social activity and improvement in depressive symptoms over a 2-year period among people scoring above case level.
Design:
A secondary analysis of data from a prospective community-based study.
Setting:
Montpellier district, France.
Participants:
Community residents aged 65 and older (N = 1,849), 85.4% of whom were reassessed after a 2-year interval.
Measurements:
Depressive symptoms were assessed using the Center for Epidemiological Studies Depression scale at baseline and follow-up, and the standard 16 + cutoff was applied to define case-level symptomatology. The primary independent variable assessed at baseline was three levels of social activity defined from a 33-point scale. Other covariates included age, gender, marital status, education, alcohol consumption, chronic illness, cognitive impairment, disability, life events, and antidepressant use at baseline and follow-up.
Results:
In the sample at baseline (N = 1,849), higher social activity was negatively associated with case-level depressive symptomatology after adjustment for potential confounders (odds ratio across three groups 0.7, 95% confidence interval 0.6-0.8). In a prospective analysis of participants above case level at baseline (N = 463), high-social activity at baseline was the only variable associated with improvement in depressive symptoms and remained significant after adjustment for all other factors (odds ratio=1.6; 95% confidence interval = 1.2-2.2).
Conclusions:
In a large community sample, higher social activity was associated with a lower risk of late-life depressive symptoms at baseline and, in those with case-level baseline symptoms, was the principal factor predicting improvement over 2-year follow-up.
Related Concept Videos
Social Relationships and Well-Being
Depressive Disorders: MDD and Dysthymia
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression
Depression: Overview