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Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation
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Published on: January 12, 2016

HIV-occlusive vascular disease.

J van Marle1, P P Mistry, K Botes

  • 1MediClinic Unit for Peripheral Vascular Surgery, Pretoria Academic Hospital, University of Pretoria.

South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
|July 25, 2009
PubMed
Summary
This summary is machine-generated.

Peripheral arterial occlusive disease in HIV patients often presents with advanced limb ischemia, leading to poor surgical outcomes and high amputation rates. Careful patient selection is crucial for intervention success.

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Area of Science:

  • Vascular Surgery
  • Infectious Diseases
  • HIV/AIDS Research

Background:

  • Peripheral arterial occlusive disease (PAOD) is a significant concern in HIV-infected patients.
  • Understanding the clinical presentation and outcomes of PAOD in this population is vital for effective management.

Purpose of the Study:

  • To evaluate the clinical presentation of peripheral arterial occlusive disease in HIV-infected patients.
  • To assess the outcomes of surgical interventions for PAOD in HIV-positive individuals.

Main Methods:

  • Prospective clinical survey of HIV-positive patients presenting to a vascular unit.
  • Enrollment in a registry and prospective follow-up of HIV+ patients.

Main Results:

  • 91 out of 154 (59%) HIV+ patients had occlusive disease, often advanced (Fontaine III/IV).
  • High rates of primary amputation (31.9%) and poor limb salvage (36.1%) for femoro-popliteal bypass.
  • Perioperative mortality was 6.95%, with long-term mortality at 20%; hypo-albuminaemia predicted poor outcomes.

Conclusions:

  • HIV-associated PAOD frequently presents with advanced disease, necessitating careful surgical candidate selection.
  • Consideration of nutritional status, immune status, and disease stage is critical for optimizing intervention outcomes.
  • Appropriate procedural selection is paramount for managing PAOD in HIV-infected patients.