Related Experiment Video
Updated: Jun 21, 2026

Assessment of Endothelial Cell Migration After Exposure to Toxic Chemicals
Published on: July 10, 2015
Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory
Gerben Bouma1, Siobhan O Burns, Adrian J Thrasher
1Centre for Immunodeficiency, UCL Institute of Child Health, London, UK. g.bouma@ich.ucl.ac.uk
Abstract:
Regulation of the actin cytoskeleton is crucial for many aspects of correct and cooperative functioning of immune cells, such as migration, antigen uptake and cell activation. The Wiskott-Aldrich Syndrome protein (WASp) is an important regulator of actin cytoskeletal rearrangements and lack of this protein results in impaired immune function. This review discusses recent new insights of the role of WASp at molecular and cellular level and evaluates how WASp deficiency affects important immunological features and how defective immune cell function contributes to compromised host defence.
Related Concept Videos
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Actin Polymerization and Cell Motility
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate.
Inflammatory Bowel Disease III: Crohn's Disease
Cell-mediated Immune Responses
Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

