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Updated: Jun 21, 2026

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
Published on: October 22, 2019
Role of airway epithelium in engulfing apoptotic eosinophils
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, AlKharaj 11942, Saudi Arabia. falenzi@ksu.edu.sa
Introduction:
This study aims to investigate which recognition pathways are important in engulfing apoptotic eosinophils.
Methods:
Here, two epithelial cell were selected namely (large airway bronchial epithelial cells) LAECs and A549. The inhibition assay was examined by resting and dexamethasone-stimulated epithelial cells. Confocal microscopy confirmed the engulfment of apoptotic eosinophils.
Results:
Macrophages and LAECs recognized and phagocytosed apoptotic eosinophils. Dexamethasone and IL-1 increased the capacity of LAECs to engulf apoptotic eosinophils. More interestingly, inhibiting monoclonal antibodies (Mabs) abolished the uptake of apoptotic cells by LAECs.
Conclusion:
On the basis of the above findings, the LAECs is capable of recognizing and engulfing apoptotic eosinophils and that enhanced by interleukin-1 (IL-1â) and dexamethasone.
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