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Updated: Jun 21, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
Stewardship of human biospecimens, DNA, genotype, and clinical data in the GWAS era
1Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702-1201, USA. obrien@ncifcrf.gov
Abstract:
An ethical quandary is emerging over custodianship of and access to DNA specimens and attached data, clinical and genetic, held in large disease cohort collections. The balance of patients' rights and science/society's quest for broad open access must be resolved in order to realize the promise of gene association studies of complex human disease. A way forward may be to convene a colloquium of international medical and science organizations charged with developing global consensus guidance and ethical principles for access to and use of genomic biobanks.
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