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[Bovine immunodeficiency virus: short review]
1Agriculture Canada, Institut de recherches vétérinaires, Nepean, Ontario, Canada.
Annales De Recherches Veterinaires. Annals of Veterinary Research
|January 1, 1990
Summary
Bovine immunodeficiency-like virus (BIV), a lentivirus, causes persistent infections in cattle and may serve as an animal model for human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). This research updates knowledge on BIV identification and characteristics.
Area of Science:
- Virology
- Immunology
Context:
- Bovine visna-like virus, initially overlooked, gained attention post-human immunodeficiency virus (HIV) discovery.
- Urgent need for animal models for acquired immunodeficiency syndrome (AIDS) research spurred renewed interest.
Purpose:
- To detail the identification stages of the bovine virus.
- To provide an updated overview of bovine immunodeficiency-like virus (BIV) knowledge.
Summary:
- Bovine immunodeficiency-like virus (BIV) is the only known bovine lentivirus, sharing traits with other lentiviruses.
- BIV establishes persistent, slow-progressive infections in cattle, affecting leukocytes and potentially causing secondary infections.
- It replicates in vitro, inducing syncytia and productive/latent infections, but is non-oncogenic.
Impact:
- BIV serves as a potential in vitro and in vivo model for studying HIV and AIDS.
- Understanding BIV's role in immune perturbations and secondary infections is crucial.
- Research contributes to the development of animal models for retroviral diseases.