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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Extensively drug-resistant tuberculosis: a new face to an old pathogen
Sheela Shenoi1, Gerald Friedland
1Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06510-8002, USA. sheela.shenoi@yale.edu
Annual Review of Medicine
|July 28, 2009
Summary
Drug-resistant tuberculosis, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, is a growing global concern. This article reviews the current status, development, management, and control strategies for drug-resistant tuberculosis.
Area of Science:
- Public Health
- Infectious Diseases
- Microbiology
Background:
- Drug resistance in tuberculosis treatment has been historically underestimated.
- Recent emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis has increased global concern.
- Clinicians and public health bodies are increasingly focused on resistant tuberculosis strains.
Purpose of the Study:
- To outline the current global epidemiology of drug-resistant tuberculosis.
- To examine the mechanisms of drug resistance development in Mycobacterium tuberculosis.
- To discuss current therapeutic approaches and future control strategies for resistant tuberculosis.
Main Methods:
- Review of global surveillance data on drug-resistant tuberculosis.
- Analysis of scientific literature on tuberculosis drug resistance mechanisms.
- Synthesis of information on current treatment regimens and public health interventions.
Main Results:
- Widespread prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis globally.
- Understanding of key pathways and factors contributing to the development of drug resistance.
- Identification of challenges and successes in managing and controlling drug-resistant tuberculosis.
Conclusions:
- Drug-resistant tuberculosis poses a significant and escalating global health threat.
- Effective management requires updated treatment strategies and robust public health programs.
- Continued research and international collaboration are crucial for controlling the spread of resistant tuberculosis.
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