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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:

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Related Experiment Video

Updated: Jun 21, 2026

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Defining human endothelial progenitor cells.

M C Yoder1

  • 1Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. myoder@iupui.edu

Journal of Thrombosis and Haemostasis : JTH
|July 28, 2009
PubMed
Summary
This summary is machine-generated.

Defining endothelial progenitor cells (EPCs) is challenging due to a lack of specific markers. Research suggests endothelial colony-forming cells are the only true human EPCs, with hematopoietic cells modulating neoangiogenesis.

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Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
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Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
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Last Updated: Jun 21, 2026

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

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Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

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Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Area of Science:

  • Cardiovascular Biology
  • Stem Cell Research
  • Angiogenesis

Background:

  • Endothelial progenitor cells (EPCs) are crucial for vascular repair and neovascularization.
  • Current definitions and markers for human EPCs are inconsistent, hindering research progress.
  • Lack of a definitive EPC marker limits the understanding of neoangiogenesis.

Purpose of the Study:

  • To review current methodologies for defining human EPCs.
  • To propose improved approaches for identifying cell populations involved in neoangiogenesis.
  • To clarify the role of different cell types in vascular network formation.

Main Methods:

  • Systematic literature search on PubMed using the term 'endothelial progenitor cell'.
  • Evaluation of articles specifically addressing the definition of EPCs.
  • Analysis of studies investigating cell contributions to neoangiogenesis.

Main Results:

  • Endothelial colony-forming cells (ECFCs) align with the original characteristics proposed for human EPCs.
  • Various hematopoietic stem and progenitor cells actively participate in initiating and regulating neoangiogenesis.
  • A distinct subset of hematopoietic cells is involved in ECFC-driven vascular network remodeling.

Conclusions:

  • Endothelial colony-forming cells represent the primary human endothelial progenitor cell population.
  • Hematopoietic cells play a significant regulatory role in neoangiogenesis alongside ECFCs.
  • Future research should focus on defining specific hematopoietic subsets that modulate ECFC function in vascularization.