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Related Experiment Video

Updated: Jun 21, 2026

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.

Miriam Fanjul-Fernández¹, Alicia R Folgueras, Sandra Cabrera

¹Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

Biochimica Et Biophysica Acta

|July 28, 2009

Summary

Matrix metalloproteinases (MMPs) are crucial enzymes involved in health and disease. Understanding their complex regulation is key to developing treatments for conditions like cancer and arthritis.

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Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

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Published on: February 22, 2016

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Last Updated: Jun 21, 2026

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Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

Area of Science:

Biochemistry
Molecular Biology
Genetics

Background:

Matrix metalloproteinases (MMPs) are a diverse family of zinc-dependent endopeptidases.
MMPs play critical roles in numerous physiological and pathological processes.
Their evolution involves gene duplication, fusion, and exon shuffling, leading to complex structures.

Purpose of the Study:

To explore the intricate regulatory mechanisms governing MMP gene expression.
To understand the implications of MMP dysregulation in various diseases.
To highlight the role of genetic and epigenetic factors in MMP activity.

Main Methods:

Analysis of transcriptional control mechanisms, including cis-regulatory elements and signaling pathways.
Investigation of epigenetic modifications like DNA methylation and histone acetylation.
Examination of post-transcriptional regulation, including mRNA stability and microRNAs.
Genomic studies and the use of gain- or loss-of-function animal models.

Main Results:

MMP expression is tightly controlled by a combination of transcriptional, epigenetic, and post-transcriptional mechanisms.
MMP polymorphisms and mutations are linked to genetic diseases.
Animal models have elucidated novel MMP functions and disease associations.

Conclusions:

MMP regulation is complex, involving multiple layers of control.
Dysregulation of MMPs is causally linked to human diseases.
Further research, including genomic studies and animal models, is needed to fully understand MMPs' roles in health and disease.