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[Radioaerosol inhalation lung imaging using technegas].

T Isawa1, T Teshima, Y Anazawa

  • 1Department of Medicine, Research Institute for Chest Diseases and Cancer, Tohoku University.

Kaku Igaku. the Japanese Journal of Nuclear Medicine
|November 1, 1990
PubMed
Summary

Technegas, a radioactive agent, effectively visualizes lung ventilation and deposition in patients with chest diseases. Its high alveolar deposition ratio aids in identifying intrapulmonary ventilation sites.

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Area of Science:

  • Nuclear Medicine
  • Pulmonary Imaging
  • Radiopharmacology

Background:

  • Accurate assessment of lung ventilation is crucial for diagnosing various chest diseases.
  • Traditional methods may have limitations in visualizing peripheral lung regions and ventilation patterns.
  • Development of novel radiopharmaceuticals for lung imaging is an ongoing area of research.

Purpose of the Study:

  • To evaluate the efficacy of a Technegas generator using technetium-99m pertechnetate for lung imaging.
  • To assess the deposition characteristics and distribution of Technegas in the lungs of normal subjects and patients with chest diseases.
  • To determine the utility of Technegas in identifying intrapulmonary sites of effective ventilation.

Main Methods:

  • Technegas was generated using 99mTc-pertechnetate and inhaled by 4 normal subjects and 31 patients with diverse chest conditions.

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  • Inhalation was performed from residual volume (RV) to total lung capacity (TLC) via mouth with nose clipping, followed by breath-holding.
  • Three deep breaths were sufficient to deliver 37-55.5 MBq of Technegas, and imaging was performed post-inhalation.

    • Main Results:

    • An average alveolar deposition ratio (ALDR) of 85% was achieved, indicating excellent penetration to the lung periphery.
    • Localized 'hot spots' of radioactive deposition were observed in cases of airway obstruction, differentiating gas and aerosol characteristics.
    • Inhalation and perfusion lung images showed high resemblance due to large ALDRs, suggesting Technegas effectively indicates intrapulmonary ventilation sites.

    Conclusions:

    • Technegas demonstrates excellent alveolar deposition and peripheral lung penetration, making it suitable for ventilation imaging.
    • The agent effectively highlights intrapulmonary ventilation sites, correlating well with perfusion imaging.
    • A noted disadvantage is the transient anoxic state of Technegas immediately after generation.