Related Experiment Video
Updated: Oct 14, 2026

Measurement of Smooth Muscle Function in the Isolated Tissue Bath-applications to Pharmacology Research
Published on: January 19, 2015
[Serum myoglobin level as a criterion of the effectiveness of adrenergic beta receptor blockaders]
Abstract:
The study was undertaken to examine 20 healthy subjects and 20 patients with Stages I and II hypertensive disease (all being males) under psycho-emotional stress (PES). In terms of relationships between blood pressure values, heart rate, and serum myoglobin (Mb) levels, it was concluded that PES caused various degrees of beta 1- and beta 2-adrenoreceptor activation. Exposing the same patients treated with obsidan to PES revealed more pronounced values and responsiveness of diastolic pressure in a subgroup of patients showing simultaneously a dramatic decrease in Mb levels, which is indicative of alpha-adrenoreceptor activation after beta 2-receptor blockade. It was proposed to apply an index of decreased Mb levels during obsidan therapy as a measure of beta 2-adrenoreceptor blockade.
More Related Videos
Related Concept Videos
Adrenergic Receptors: β Subtype
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors have equal affinities for...
Adrenergic Antagonists: Chemistry and Classification of ɑ-Receptor Blockers
Nonselective α-blockers: Nonselective α-blockers contain haloalkylamine or imidazoline moieties. Phenoxybenzamine, with a haloalkylamine...
Adrenergic Antagonists: Chemistry and Classification of β-Receptor Blockers
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers
Adrenergic Antagonists: ɑ and β-Receptor Blockers
Heart Failure Drugs: β-Blockers

