Calcium regulating the polarity: a new pathogenesis of aphthous ulcer

Aphthous ulcer is one of the most common oral conditions. Although many etiological factors have been presented, its precise cause remains unclear. Not only is calcium an integral part of the teeth and bones, but it is a second messenger involving in many physiological processes. Recently, with the study of calcium in polarity of cells or tissues, it was found that calcium can regulate the polarity of cells or tissues. The polarity of cells or tissues is the classic feature of metazoan, and this polarity makes sure the performing of cell or tissue's functions correctly. The polarity of oral mucous just likes a defender acting as a barrier to resist against external stimulation. So, we hypothesize that deficiency of calcium may be a new wire-puller of aphthous ulcer. That means, deficiency of calcium which may bring about the loss of polarity, could be a new pathogenesis of aphthous ulcer, meanwhile, supplement of calcium is necessary for gestation in order to avoid not only occurrence of osteoporosis and hypertension, but also prevention of aphthous ulcer and healing of focus.