Related Experiment Video
Updated: Jun 21, 2026
07:44
Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
Published on: March 12, 2018
Pulmonary metastases from parachordoma.
Filippo Lococo1, Alfredo Cesario, Elisa Meacci
1Department of Thoracic Surgery, Catholic University and Scientific Direction, Rome, Italy. filippo_lococo@yahoo.it
The Annals of Thoracic Surgery
|July 28, 2009
Summary
Metastatic parachordoma to the lung is rare. This case report details a young woman with iliopsoas muscle parachordoma who developed lung metastases, highlighting the potential for indolent tumors to spread.
Area of Science:
- Oncology
- Pathology
Background:
- Parachordoma is a rare tumor typically exhibiting indolent behavior.
- Surgical resection is the primary treatment for localized parachordoma.
Observation:
- A young woman presented with a solitary pulmonary nodule on routine CT scan.
- The nodule was diagnosed as metastatic parachordoma from a prior iliopsoas muscle tumor.
- This represents a rare instance of parachordoma lung metastasis.
Findings:
- Metastatic parachordoma to the lung was confirmed histopathologically.
- The patient received adjuvant imatinib (Glivec) chemotherapy for 10 months.
- No tumor recurrence was observed at the time of reporting.
Implications:
- This case adds to the limited literature on parachordoma lung metastases.
- It underscores that even indolent parachordomas can metastasize, necessitating vigilant follow-up.
- Further research into the metastatic potential and optimal management of parachordoma is warranted.
Related Concept Videos
01:17Other Pulmonary Disorders
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
01:29Pulmonary Embolism I: Introduction
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
01:19Pulmonary Embolism I: Introduction
A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
01:27Pneumothorax-II
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
01:13Pleura of the Lungs
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
02:30Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...