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Activation of the anticancer drug CCNU into a free radical intermediate via UV irradiation--an ESR study
Z D Raikov1, A M Zheleva, E T Raikova
1Department of Chemistry and Biochemistry, Laboratory of Molecular Oncology, Stara Zagora, Bulgaria.
Free Radical Biology & Medicine
|January 1, 1990
Abstract:
We studied the formation of a free radical induced by UV irradiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in benzene. It was determined a stable nitroxide radical by ESR spectroscopy. We confirmed that sterically hindered cyclic amine 2,2,6,6-tetramethyl-4-piperidone (TMPone) was transformed into a corresponding stable free nitroxyl radical during UV irradiation. When CCNU was present, the rate of free radical formation from TMPone increased considerably.