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Synthesis and antitumour activity of 4-nitroso-4-(2-chloroethyl)semicarbazides
R G Gugova1, Z D Raikov, S G Zakhariev
1Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia.
Drugs Under Experimental and Clinical Research
|January 1, 1989
Abstract:
1-Methyl-1-(2-chloroethyl)-4-nitroso-4-(2-chloroethyl)semicarbazide, 1,1-di-(2-chloroethyl)-4-nitroso-4-(2-chloroethyl)semicarbazide and 1,1-di-(2-bromoethyl)-4-nitroso-4-(2-chloroethyl)semicarbazide, which are a novel class of nitrosoureas containing hydrazinomustard residue, have been synthesized. A dose-dependent antitumour activity was found with the three tested compounds.