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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Updated: Jun 21, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Published on: January 19, 2010

Sickle cell-induced ischemic colitis.

Camille L Stewart1, Geraldine E Ménard

  • 1Section of General Internal Medicine, Tulane University School of Medicine, 1430 Tulane Ave, SL-16, New Orleans, LA 70112, USA.

Journal of the National Medical Association
|July 29, 2009
PubMed
Summary
This summary is machine-generated.

Sickle cell-induced ischemic colitis is a rare complication of sickle cell anemia. Early diagnosis and treatment are crucial to differentiate it from pain crises and prevent severe outcomes.

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Area of Science:

  • Gastroenterology
  • Hematology
  • Internal Medicine

Background:

  • Sickle cell anemia (SCA) patients are at risk for vaso-occlusive events affecting various organs.
  • Ischemic colitis is a rare but serious complication of SCA, often presenting with abdominal pain that can mimic typical pain crises.
  • Delayed diagnosis of ischemic colitis in SCA can lead to significant morbidity and mortality.

Observation:

  • A 29-year-old female with SCA presented with left lower quadrant abdominal pain.
  • Diagnostic workup included laboratory tests, imaging (CT scan), and colonoscopy.
  • The patient's symptoms were initially attributed to a pain crisis, delaying the diagnosis of ischemic colitis.

Findings:

  • The case underscores the challenge in distinguishing SCA pain crises from ischemic colitis.
  • Comprehensive diagnostic evaluation is essential for accurate diagnosis.
  • Literature review suggests a diagnostic and treatment approach for this condition.

Implications:

  • Highlights the need for heightened clinical suspicion for ischemic colitis in SCA patients with abdominal pain.
  • Emphasizes the importance of a thorough diagnostic workup beyond typical pain crisis management.
  • Provides insights into the diagnosis and management of sickle cell-induced ischemic colitis.