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Neurohypophysial peptides selectively depressed high voltage-activated Ca-current in snail neurons
1Department of General Physiology of the Nervous System, A.A. Bogomoletz Institute, Academy of Sciences of the Ukrainian S.S.R., Kiev.
Neuroscience Letters
|November 27, 1990
Abstract:
It was found that neurohypophysial peptides oxytocin and Lys-vasopressin selectively decreased the high voltage-activated component of the inward Ca-current in voltage-clamped Helix pomatia identified neurons in a dose- and time-dependent manner. This effect was unaffected or further enhanced applying phosphodiesterases inhibitors. It is suggested that suppression of high voltage-activated current was due to the activation of the adenylate cyclase system, likely protein kinase A.