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Updated: Jun 21, 2026

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
Published on: November 1, 2024
1H and 15N resonance assignment of the second fibronectin type III module of the neural cell adhesion molecule
Vladislav V Kiselyov1, Vladimir Berezin, Elisabeth Bock
1Protein Laboratory, Institute of Molecular Pathology, Blegdamsvej 3, Copenhagen, Denmark. vkis@novonordisk.com
Abstract:
We report here the NMR assignment of the second fibronectin type III module of the neural cell adhesion molecule (NCAM). This module has previously been shown to interact with the fibroblast growth factor receptor (FGFR), and the FGFR-binding site was mapped by NMR to the FG-loop region of the module. The FG-loop region also contains a putative nucleotide-binding motif, which was shown by NMR to interact with ATP. Furthermore, ATP was demonstrated to inhibit binding of the second F3 module of NCAM to FGFR.
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