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Updated: Oct 8, 2026
Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
Published on: June 19, 2015
Expeditious synthesis of fluorogenic enzyme substrates for mucopolysaccharidosis types I and II
Yuchen Pan1, Guoqing Zhang1, Norbert Wimmer1
1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia. v.ferro@uq.edu.au.
Abstract:
New, rapid and inexpensive syntheses of 4-methylumbelliferyl fluorogenic substrates for α-L-iduronidase and iduronate-2-sulfatase, have been developed from a common β-D-glucuronosyl fluoride intermediate. The syntheses feature an efficient purple light-promoted, CCl4-free, one-pot Ferrier photobromination/radical debromination sequence for the key C-5 epimerization. The substrates are useful chemical tools for studying mucopolysaccharidosis type I (MPS I) and type II (MPS II).
