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Published on: December 9, 2017
N-Acetylation of aromatic amines using copper acetate as an acetyl source
Yash Dhaduk1, Maulik Pethani1, Shreeya Dave1
1Department of Chemistry, Sardar Vallabhbhai National Institute of Technology Surat, Gujarat - 395 007, India. togatinaveen123@gmail.com.
Abstract:
Amide bond formation is fundamental to organic synthesis because amides are prevalent in pharmaceuticals, bioactive molecules, and industrial materials. Herein, we report a simple and efficient method for amine acetylation using copper acetate as the acetylating reagent and AIBN as the radical initiator. The reaction proceeds without additional catalysts or an inert atmosphere, offering an economical, environmentally friendly, and practical approach to synthesizing aromatic amides for research applications. To the best of our knowledge, this is the first report describing the N-acetylation of aromatic amines using copper acetate as the acetylating reagent.
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