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Published on: September 12, 2019
[A comparison of three methods in establishing transplanted model of VX2 tongue carcinoma in rabbits]
Jun Tian1, Gui-Qing Liao, Hai-Chao Liu
1Dept. of Oral and Maxillofacial Surgery, Stomatological Hospital, Sun Yat-Sen University, Guangzhou 510055, China.
Objective:
To establish transplanted models of VX2 tongue carcinoma in rabbits by three methods and compare these models.
Methods:
After establishment of VX2 tumor-bearing rabbits, 72 New-Zealand white rabbits were randomly divided into 3 groups. Intact tumour tissue, modified tumour cell suspension, tumour cell suspension were respectively injected into the middle-third lateral border of the tongues of rabbits in 3 groups to induce transplanted VX2 tongue carcinoma. The histological features, the tumour-take rates and the metastasis rates of the 3 models were observed.
Results:
The tumour-take rate of 3 models were 83.3%, 91.7% and 33.3% respectively; the lymph node metastasis rates were 71.4%, 100.0% and 37.5% respectively; the lung metastasis rates were 35.7%, 81.3% and 0 respectively. The histological features of the transplanted VX2 tongue carcinoma of 3 models were all consistent with those of moderately differentiated carcinoma.
Conclusion:
The biological properties of the transplanted VX2 tongue carcinoma of 3 models is much alike to tongue carcinoma in humans. The model established with modified tumor cell suspension is considered to be more suitable for tongue cancer study.
