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Updated: Jun 21, 2026

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
Published on: September 21, 2015
Prophylactic use of isepamicin and levofloxacin for transrectal prostate biopsy: a retrospective single center study
Katsumi Shigemura1, Tomihiko Yasufuku, Masuo Yamashita
1Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. katsumiatlanta@hotmail.com
Objectives:
To evaluate the combination of isepamicin and levofloxacin in the prophylaxis of infectious complications associated with prostate biopsy (PBX).
Methods:
A total of 586 patients who underwent transrectal PBX in a single center were included in this retrospective analysis. They received 400 mg isepamicin once just before PBX plus 300 mg oral levofloxacin each day for three days as a rule. Clinical and laboratory data were evaluated.
Results:
A total of three (0.51%) patients presented a febrile complication after PBX. All of them were diagnosed as acute prostatitis. Serum white blood cell count and C-reactive protein in the 131 patients whose laboratory data were available for statistical analyses did not rise significantly after PBX.
Conclusions:
Isepamicin plus fluoroquinolone can be considered a valuable regimen for antibiotic prophylaxis of PBX.
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