Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-term clinical outcomes after Lyme neuroborreliosis in children.

BMC pediatrics·2025

Same author

Editorial: Pediatric critical care in low resource settings.

Frontiers in pediatrics·2024

Same author

UNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings.

Developmental cognitive neuroscience·2024

Same author

Prevalence of early postpartum depression and associated risk factors among selected women in southern Malawi: a nested observational study.

BMC pregnancy and childbirth·2023

Same author

Clinical manifestations of Lyme neuroborreliosis in children: a review.

European journal of pediatrics·2023

Same author

Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study.

PloS one·2022

Same journal

HER2-low as a unique subgroup in breast cancer: insights from neoadjuvant chemotherapy response and survival analysis.

Journal of clinical pathology·2026

Same journal

Polyp-forming Dieulafoy lesion of the rectum.

Journal of clinical pathology·2026

Same journal

Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

Journal of clinical pathology·2026

Same journal

MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

Journal of clinical pathology·2026

Same journal

Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

Journal of clinical pathology·2026

Same journal

MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

Journal of clinical pathology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

Improved method for assessing iron stores in the bone marrow.

K S Phiri¹, J C J Calis, D Kachala

¹Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, PO Box 30096, Blantyre 3, Malawi. kamijaphiri@gmail.com

Journal of Clinical Pathology

|July 30, 2009

Summary

This summary is machine-generated.

A refined bone marrow iron assessment method improves iron deficiency diagnosis in children. This intensive examination offers a more accurate iron status classification, crucial for areas with high inflammation rates.

More Related Videos

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

A Colorimetric Method for Measuring Iron Content in Plants

A Colorimetric Method for Measuring Iron Content in Plants

Published on: September 7, 2018

Related Experiment Videos

Last Updated: Jun 21, 2026

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

A Colorimetric Method for Measuring Iron Content in Plants

A Colorimetric Method for Measuring Iron Content in Plants

Published on: September 7, 2018

Area of Science:

Hematology
Pediatric Nutrition
Clinical Pathology

Background:

Bone marrow iron microscopy is the gold standard for assessing iron deficiency.
Current grading methods for bone marrow iron are subjective and lack precision.

Purpose of the Study:

To develop a detailed protocol for assessing iron in bone marrow fragments, macrophages, and erythroblasts.
To enhance the objectivity and accuracy of bone marrow iron grading.

Main Methods:

A descriptive study involving 303 anemic children (6-60 months) and 22 controls in Malawi.
Utilized an intensive bone marrow iron grading method for detailed assessment.

Main Results:

The intensive method identified iron store deficiency in 22% of cases and 39% of controls.
Functional iron deficiency was found in 40% of cases and 46% of controls.
Functional iron deficiency correlated with elevated C-reactive protein; iron store deficiency correlated with increased soluble transferrin receptor.

Conclusions:

An intensive bone marrow examination significantly improves iron assessment accuracy.
This method provides a valuable iron status classification, especially in regions with high inflammatory conditions.