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A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT
Published on: June 12, 2020
Human cortical bone: the SiNuPrOs model. Part II--a multi-scale study of permeability.
M Predoi-Racila1, M C Stroe, J M Crolet
1Department of Applied Mathematics, University of Craiova, Craiova, Romania.
Summary
This study introduces a multi-scale approach to accurately determine cortical bone permeability, a key property for understanding its porous nature. The new model aligns well with experimental data, resolving discrepancies in previous measurements.
Area of Science:
- Biomaterials Science
- Computational Mechanics
- Bone Physiology
Background:
- Cortical bone is increasingly recognized as a porous medium, necessitating the accurate determination of its physical properties.
- While bone porosity is relatively well-understood, measuring its permeability presents significant challenges, leading to wide experimental variations (10^-13 to 10^-23 m^2).
- Discrepancies in experimental permeability values suggest that current measurement methods may not capture the complexity of bone's porous structure.
Purpose of the Study:
- To propose a novel multi-scale model for calculating the permeability of cortical bone.
- To address the challenges in accurately measuring bone permeability by considering its architectural complexity.
- To provide a computational framework for determining permeability tensor coefficients within a multi-scale context.
Main Methods:
- Development of a multi-scale medium concept for cortical bone, integrating architectural levels from the SiNuPrOs model.
- Application of mathematical homogenization theory to each architectural level of the bone structure.
- Numerical computation of permeability tensor coefficients based on the multi-scale model.
Main Results:
- The proposed multi-scale model enables a more accurate numerical computation of cortical bone permeability.
- Simulations derived from the model demonstrate good agreement with previously published experimental results.
- The multi-scale approach helps to reconcile the wide range of experimental permeability values by accounting for different structural scales.
Conclusions:
- The multi-scale modeling approach provides a robust method for characterizing cortical bone permeability.
- This study offers a new perspective on bone permeability, resolving inconsistencies in experimental data.
- The findings are crucial for advancing our understanding of fluid flow and transport phenomena in bone tissue.
