Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

Compact Bone

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...

Bone as Supporting Connective Tissue

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Spongy Bone

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...

Collagens are the Major Structural Proteins of ECM

Collagens are the Major Structural Proteins of ECM

Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Numerical simulations in a bony callus.

Computer methods in biomechanics and biomedical engineering·2014

Same author

Dissecan osteochondritis of the elbow: a possible explanation with a numerical study.

Computer methods in biomechanics and biomedical engineering·2013

Same author

Simulation of bone ingrowth in non-resorbable substitutes.

Computer methods in biomechanics and biomedical engineering·2013

Same author

Effect of macroscopic loading on nanoscopic signal for cellular activity.

Computer methods in biomechanics and biomedical engineering·2012

Same author

Mechanotransduction in cortical bone and the role of piezoelectricity: a numerical approach.

Computer methods in biomechanics and biomedical engineering·2011

Same author

Human cortical bone: the SiNuPrOs model. Part II--a multi-scale study of permeability.

Computer methods in biomechanics and biomedical engineering·2009

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Collagen's role in the cortical bone's behaviour: a numerical approach.

M Predoi-Racila¹, J M Crolet

¹Department of Applied Mathematics, University of Craiova, Romania.

Computer Methods in Biomechanics and Biomedical Engineering

|March 11, 2011

Summary

This summary is machine-generated.

The elastic properties of human cortical bone vary due to sample location. This study uses a numerical model to show collagen fiber orientation significantly impacts bone

More Related Videos

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT

Published on: June 12, 2020

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests

Published on: November 30, 2017

Related Experiment Videos

Last Updated: Jun 3, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT

Published on: June 12, 2020

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests

Published on: November 30, 2017

Area of Science:

Biomechanics
Materials Science
Orthopedics

Background:

Experimental measurements of human cortical bone's elastic properties show wide value variations.
This heterogeneity is linked to bone structure and sampling area, but reasons are not fully understood.
Ultrasonic measurements reveal complex elastic property maps in cortical bone.

Purpose of the Study:

To propose an explanation for the heterogeneity in human cortical bone's elastic properties.
To investigate the influence of mineral apposition around collagen fibers on bone's mechanical behavior.
To quantify the effect of collagen fiber spatial orientation on cortical bone's elastic properties and anisotropy.

Main Methods:

Development and application of a numerical model for human cortical bone (SiNuPrOs model).
Utilizing homogenization theory to calculate the elasticity tensor components.
Analyzing the impact of collagen fiber orientation on bone's elastic properties.

Main Results:

The spatial orientation of collagen fibers significantly influences the elastic properties of human cortical bone.
The study quantifies the main effect of architectural orientation on bone's mechanical behavior.
Collagen fiber orientation is identified as a key factor contributing to the anisotropy of cortical bone.

Conclusions:

Mineral apposition around collagen fibers, influenced by their orientation, is a primary driver of cortical bone's elastic heterogeneity.
The SiNuPrOs model provides insights into the relationship between bone's micro-architecture and its macroscopic elastic properties.
Understanding this orientation-property relationship is crucial for applications in orthopedics and biomaterials.