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Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts
Published on: October 25, 2011
Vulvar mammary-type myofibroblastoma: a case report
Gouri B Diwadkar1, Matthew D Barber
1Urogynecology and Reconstructive Surgery, Obstetrics, Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA. diwadkg@ccf.org
The Journal of Reproductive Medicine
|July 31, 2009
Summary
This is the first reported case of a vulvar myofibroblastoma, a rare tumor typically found along the mammary midline. Surgical removal is recommended due to its adherence to surrounding tissues.
Area of Science:
- Gynecologic Pathology
- Surgical Oncology
Background:
- Mammary-type myofibroblastomas are rare mesenchymal tumors.
- Extramammary myofibroblastomas have been documented, primarily along the mammary midline.
- Vulvar myofibroblastomas have not been previously reported.
Observation:
- A 56-year-old woman presented with a vulvar mass, pelvic organ prolapse, and urinary incontinence.
- A 3-cm firm vulvar mass was identified near the Bartholin's gland.
Findings:
- This case represents the first documented instance of a myofibroblastoma occurring in the vulva.
- The vulvar myofibroblastoma exhibited dense adherence to surrounding tissues.
Implications:
- The first report of vulvar myofibroblastoma expands the known anatomical distribution of these tumors.
- Difficult dissection due to tissue adherence necessitates careful surgical planning.
- Surgical excision in an operating room setting with appropriate equipment and sedation is advised for vulvar myofibroblastomas.
