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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Related Experiment Video

Updated: Jun 21, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Surface plasmon resonance imaging for biosensing.

S Paul1, P Vadgama, A K Ray

  • 1Queen Mary, University of London, School of Engineering and Materials Science, London, UK.

IET Nanobiotechnology
|July 31, 2009
PubMed
Summary
This summary is machine-generated.

Surface plasmon resonance imaging (SPRI) offers label-free detection for biomolecular interactions. This review details SPRI systems, applications, signal amplification, and sensitivity compared to other methods.

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Last Updated: Jun 21, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
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Published on: March 20, 2015

Area of Science:

  • Biophysics
  • Analytical Chemistry
  • Biotechnology

Background:

  • Surface plasmon resonance imaging (SPRI) is a powerful technique for analyzing surface biomolecular interactions.
  • It enables label-free detection and utilizes sophisticated instrumentation.

Purpose of the Study:

  • To review the SPRI imaging system and its recent applications.
  • To highlight high-throughput analysis of diverse biological interactions.
  • To introduce signal amplification strategies and compare SPRI sensitivity with competing methods.

Main Methods:

  • Description of SPRI imaging system principles.
  • Review of recent literature on SPRI applications in biological studies.
  • Discussion of signal amplification techniques including nanoparticle and waveguide-based optical coupling.
  • Comparative analysis of SPRI detection sensitivity.

Main Results:

  • SPRI is effective for studying various biological interactions with high throughput.
  • Nanoparticle and waveguide-based methods enhance SPRI signal.
  • SPRI demonstrates competitive detection sensitivity compared to other techniques.

Conclusions:

  • SPRI is a versatile and sensitive tool for label-free analysis of biomolecular interactions.
  • Advancements in signal amplification improve SPRI performance.
  • SPRI remains a competitive method in the field of biosensing.