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Updated: Jun 21, 2026
06:03
Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens
Published on: September 20, 2024
Immunological disturbances in Good's syndrome
Justyna Fijolek1, Elzbieta Wiatr, Urszula Demkow
1Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
Summary
Good's syndrome, a rare immunodeficiency linked to thymoma, presents with adult-onset hypogammaglobulinaemia. Early diagnosis through immunoglobulin measurement is crucial for patients with suspected thymoma.
Area of Science:
- Immunology
- Oncology
Background:
- Good's syndrome is a rare condition characterized by adult-onset hypogammaglobulinaemia associated with thymoma.
- It presents a diagnostic challenge due to its rarity and complex clinical manifestations.
Observation:
- A case report details a 38-year-old woman with an upper mediastinal mass and persistent lung infiltrates.
- Despite thymectomy and antibiotics, her condition, including bronchiectasis and opacities, did not improve.
Findings:
- Immunological analysis revealed very low serum immunoglobulin levels and impaired T cell response to Staphylococcus aureus Cowan I.
- Flow cytometry showed a severe reduction in B-cells at all developmental stages (CD10+CD19+, CD5+CD20).
- Diagnosis of Good's syndrome was confirmed, with improvement following intravenous immunoglobulin therapy.
Implications:
- This case underscores the importance of considering Good's syndrome in patients with thymoma and recurrent infections.
- Measuring serum immunoglobulin levels is recommended for individuals suspected of having thymoma to facilitate early diagnosis and management.
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