Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Ovariectomy vs. hypofunction: their effects on rat mandibular bone.

S C F Rawlinson¹, A Boyde, G R Davis

¹Centre for Adult Oral Health, Institute of Dentistry, Queen Mary University of London, Barts, and The London School of Medicine & Dentistry, Turner Street, Whitechapel, London E1 2AD, UK.

Journal of Dental Research

|July 31, 2009

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Topographically guided hierarchical mineralization.

Materials today. Bio·2021

Same author

The plate-to-rod transition in trabecular bone loss is elusive.

Royal Society open science·2021

Same author

Periodontal diagnosis in the context of the 2017 classification system of periodontal diseases and conditions: presentation of a patient with periodontitis localised to the molar teeth.

British dental journal·2019

Same author

Periodontal diagnosis in the context of the 2017 classification system of periodontal diseases and conditions: Presentation of a middle-aged patient with localised periodontitis.

British dental journal·2019

Same author

Periodontal diagnosis in the context of the 2017 classification system of periodontal diseases and conditions - implementation in clinical practice.

British dental journal·2019

Same author

Periodontal diagnosis in the context of the BSP implementation plan for the 2017 classification system of periodontal diseases and conditions: presentation of a pair of young siblings with periodontitis.

British dental journal·2019

Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026

Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026

Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026

Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026

Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026

Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026

See all related articles

Mandibular bone is more affected by mechanical loading than hormones. Unilateral mandibular hypofunction, not ovariectomy, increased bone mineralization and cell density in rats.

Area of Science:

Biomineralization
Bone Physiology
Skeletal Biology

Background:

Mechanical loading and hormonal factors influence bone remodeling.
The mandible's response to these factors requires further investigation.

Purpose of the Study:

To compare the effects of ovariectomy (OVX) and unilateral mandibular hypofunction on mandibular bone.
To test the hypothesis that hypofunction has a greater influence than OVX on mandibular bone.

Main Methods:

Ovariectomy (OVX) or induction of unilateral mandibular hypofunction in two-month-old rats.
Assessment of bone using micro-computed tomography (muCT), quantitative back-scattered electron analysis (qBSE-SEM), and light microscopy after 5 months.
Analysis of calvarial, maxillary, and mandibular alveolar bone.

More Related Videos

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration

Published on: June 7, 2012

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Related Experiment Videos

Last Updated: Jun 21, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration

Published on: June 7, 2012

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Main Results:

Ovariectomy (OVX) reduced bone mineralization density in calvarial, maxillary, and mandibular alveolar bone.
Unilateral mandibular hypofunction increased mineralization density in lingual mandibular alveolar bone compared to controls.
OVX reduced osteocyte density, while hypofunction increased it in alveolar bone.

Conclusions:

Mandibular bone is more sensitive to mechanical loading (hypofunction) than to hormonal changes (OVX).
Hypofunction leads to increased mineralization and cellularity in mandibular alveolar bone.
Ovariectomy results in decreased mineralization density and osteocyte numbers in alveolar bone.