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Related Experiment Video

Updated: Jun 21, 2026

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
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Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice.

James David Jentsch1, Heather Trantham-Davidson, Corey Jairl

  • 1Department of Psychology, University of California, Los Angeles, CA 90095-1563, USA. jentsch@psych.ucla.edu

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|July 31, 2009
PubMed
Summary

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Reduced dysbindin protein (DTNBP1) impairs spatial working memory and prefrontal cortex excitatory transmission in mice. This suggests dysbindin

Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Molecular Psychiatry

Background:

  • The DTNBP1 gene and its protein, dysbindin, are linked to schizophrenia and cognitive deficits.
  • Dysbindin is expressed in forebrain glutamatergic neurons, interacting with proteins in vesicular trafficking and exocytosis.

Purpose of the Study:

  • To investigate cellular, physiological, and behavioral effects of reduced dysbindin expression.
  • To elucidate the role of dysbindin in prefrontal cortex function and cognitive processes.

Main Methods:

  • Utilized mice with a null mutation in the dtnbp1 gene.
  • Assessed spatial working memory in mutant and wild-type mice.
  • Electrophysiological recordings in prefrontal cortex pyramidal neurons of mutant mice.

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Last Updated: Jun 21, 2026

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
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Published on: July 29, 2025

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice
17:45

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

Main Results:

  • Dysbindin mutant mice exhibited impaired spatial working memory; heterozygotes showed intermediate deficits.
  • Reduced paired-pulse facilitation and excitatory post-synaptic currents in mutant mice.
  • Elevated neuronal spike thresholds and evidence of altered pre-synaptic glutamatergic terminal function.

Conclusions:

  • Dysbindin significantly regulates excitatory transmission in the prefrontal cortex, likely via a pre-synaptic mechanism.
  • Dysbindin's regulation of prefrontal cortex function is critical for cognitive processes.
  • Findings offer insights into molecular mechanisms of cortical dysfunction in schizophrenia.