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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
[Cryptogenic infarct. A follow-up period of 1 year study]
E Palomeras Soler1, P Fossas Felip, A T Cano Orgaz
1Unitat de Neurología, Hospital de Mataró, Mataró, Barcelona. epalomeras@csdm.cat
Insights
Stroke recurrence and cardiovascular events were low in patients with cryptogenic infarct (CI). Atrial fibrillation (AF) was detected in 6.54% of patients within one year, particularly those with cortical middle cerebral artery (MCA) territory infarcts.
Area of Science:
- Neurology
- Cardiology
- Epidemiology
Context:
- Cryptogenic infarct (CI) represents a significant portion of ischemic strokes.
- Understanding the long-term outcomes of CI patients is crucial for risk stratification and management.
- Previous studies have varied in their follow-up durations and outcome assessments for CI.
Purpose:
- To analyze the 1-year outcomes of patients diagnosed with cryptogenic infarct (CI).
- To assess the incidence of stroke recurrence and cardiovascular events following a CI.
- To identify specific risk factors or patterns associated with adverse events in CI patients.
Summary:
- A prospective registry identified 121 patients with CI over 4 years, with a mean age of 70.6 years.
- During 1-year follow-up, 6.54% developed atrial fibrillation (AF), and 2.76% experienced recurrent ischemic stroke.
- Myocardial infarction occurred in 2 patients, and 4 deaths were recorded during the follow-up period.
Impact:
- The study indicates a low rate of stroke recurrence and cardiovascular events post-CI.
- Early detection of atrial fibrillation (AF) is important, especially in patients with cortical middle cerebral artery (MCA) territory infarcts.
- Findings contribute to better understanding and management strategies for cryptogenic stroke.
Objective:
To analyze the outcome of patients with a cryptogenic infarct (CI) after a follow-up period of 1 year.
Methods:
From our prospective registry of stroke, during a 4-year period, we've identified 121 consecutive patients with a CI (15.1% of all infarcts). They have been followed up for 1 year and we have registered stroke recurrence, cardiovascular events and other incidences.
Results:
Mean age 70.6 years-old, 53% male. Middle cerebral artery (MCA) was the most often involved territory (52 cases), 70% of them with cortical involvement. No patient died during admission, 95.8% received antiplatelet therapy and 4.1% oral anticoagulant. Fourteen patients were lost of follow-up. During 1-year period, atrial fibrillation (AF) was detected in 7 patients (6.54%), their mean age was 75 years-old, in 5 of them the CI was in MCA territory (4 with cortical involvement, 1 only deep infarct). Three patients (2.76%) suffered a recurrent ischemic stroke, in weeks 15, 16 and 44 after the CI. In all 3 cases the infarct was considered cryptogenic again. Two patients suffered a myocardial infarction and 4 died during follow-up period.
Conclusion:
In our series rate of stroke recurrence and cardiovascular events after a CI was low. An 11% of patients with a CI involving cortical MCA territory developed FA during the following year.
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